学术讲座通知

报告时间：2017年11月2日（星期四）上午10:00-11:30

报告题目：Development of novel anti-angiogenic therapies for treating ocular neovascularization diseases  

报告人：美国路易斯维尔大学Dr. Qingxian Lu

地点：下沙校区1号实验楼406室

报告人简介：

   Dr. Qingxian Lu，男，博士生导师。1983年毕业于山东大学，获生物学学士学位；1998年毕业于北京协和医学院，获细胞生物学硕士学位；1992年毕业于德克萨斯大学健康科学中心，获分子生物学硕士学位；同年进入德克萨斯大学MD Anderson癌症中心，于1996年获基因与发育生物学博士学位；1997 – 2000年在美国加州Salk生物研究所分子神经生物学实验室从事博士后研究工作；2000 – 2003年担任Salk生物研究所高级研究助理（Sr Research Associate）；2003 – 2006年担任Staff Scientist；2006 – 2012年在美国路易斯维尔大学担任眼科助理教授（Asst Professor）；2012-至今，担任路易斯维尔大学担任眼科副教授（Associate Professor）。Dr. Qingxian Lu在Nature、Science等杂志上发表多篇高水平论文，是该领域的知名专家。

欢迎广大师生积极踊跃参加！

代表性论文

1.       Lu Q, Hasty P, Shur BD. Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality. Dev Biol. 1997 Jan 15;181(2):257-67. PMID:9013935

2.       Lu Q, Shur BD. Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development. 1997 Oct;124(20):4121-31. PMID:9374408

3.       Lu Q, Gore M, Zhang Q, Camenisch T, Boast S, Casagranda F, Lai C, Skinner MK, Klein R, Matsushima GK, Earp HS, Goff SP, Lemke G. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8. PMID:10227296.

4.       Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science. 2001 Jul 13;293(5528):306-11. PMID:11452127.

5.       Lemke, G and Lu, Q. Macrophage regulation by Tyro 3 family receptors. Current Opinion in Immunology. (2003), 15(1):31-6.

6.       Caraux A, Lu Q (Co-1st author), Fernandez N, Riou S, Di Santo JP, Raulet DH, Lemke G, Roth C. Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol. 2006 Jul;7(7):747-54.PMID:16751775.

7.       Prasad, D., Rothlin, CV., Burrola, P., Burstyn-Cohen, T., Lu, Q., Garcia de Frutos, P., and Lemke, G. TAM receptor function in the retinal pigment epithelium. Mol. Cell. Neurosci. 2006, 33:96-108. PMID: 16901715.

8.       Tang Y, Lu Q-J, Wei Y, Han L, Ji R, Li Q, and Lu Q. Mertk deficiency alters expression of microRNAs in the retinal pigment epithelium cells. Metabolic Brain Diseases. 2015 Jan 22. PMID:25604732. PMC4492868.

9.       Tang Y, Wu S, Liu Q, Xie J, Zhang J, Han D, Lu Q, Lu Q. Mertk deficiency affects macrophage directional migration via disruption of cytoskeletal organization. PLoS One. 2015 Jan 24;10(1):e0117787. doi: 10.1371/journal.pone.0117787. eCollection 2015. PMID:25617898, PMC4305281.

10.   Ye F, Li Q, Ke Y, Lu Q, Han L, Kaplan HJ, Shao H, Lu Q. TAM receptor knockout mice are susceptible to retinal autoimmune induction. Invest Ophthalmol Vis Sci. 2011 Jun 16;52(7):4239-46. PMID:21467176. PMCID: PMC3175940.

11.   Ye F, Han L, Lu Q, Dong W, Chen Z, Shao H, Kaplan HJ, Li Q, Lu Q. Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice. J Immunol. 2011 Oct 15;187(8):4178-86. PMID:21918185. PMCID:PMC3190567.

12.   Li Q, Lu Q, Lu H, Tian S, Lu Q. Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death. PLoS One. 2013 Jun 20;8(6):e64812. PMID:23840307. PMCID:PMC3688737.

13.   Ji R, Tian S, Lu HJ, Lu Q, Zheng Y, Wang X, Ding J, Li Q, Lu Q. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol. 2013 Dec 15;191(12):6165-77.

14.   Ji R, Meng L, Jiang X, Cvm NK, Ding J, Li Q, Lu Q. TAM Receptors Support Neural Stem Cell Survival, Proliferation and Neuronal Differentiation. PLoS One. 2014;9(12):e115140.

15.   Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F, Verma IM. Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12425-30. PMID:16116086. PMCID:PMC1194954.

16.   Lv H, Lu Q, Zheng Y, Li Q. Notch signaling promotes the corneal epithelium wound healing. Mol Vis. 2012;18:403-11. PMID: 22355251. PMCID: PMC3283215.

17.   Hajrasouliha AR, Jiang G, Lu Q, Lu H, Kaplan HJ, and Shao H. Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization. The Journal of biological chemistry. 2013; 288(39):28058-67. PMID: 23926109 PMCID: PMC3784718

18.   Lu, H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan, HJ, and Li Q. IKK2 inhibition attenuates laser-induced choroidal neovascularization. PLOS ONE 9(1): e87530 (2014). PMID: 24489934. PMCID: PMC3905033.

19.   Gaddipati S, Lu Q, Kasetti RB, Miller MC, Lu Q, Trent JO, Kaplan HJ, Li Q. IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment. PLoS One. 2015 Mar 24;10(3):e0121185. doi: 10.1371/journal.pone.0121185. PMID: 25803615