题 目：突触上的谷氨酸受体

时 间：2016年10月27日（星期四） 上午10:30-11:30

地 点：1号楼406室

报告人：南京大学模式动物研究所石云教授

报告人简介：

 石 云，南京大学模式动物研究所神经生物学教授。1997年获得南京大学生物科学与技术系学士学位，2007年获美国佐治亚州立大学生物系博士学位。

 1997-2001南京医科大学助教，2008-2012，美国加州大学旧金山分校药理系博士后，师从Roger Nicoll 院士；2013年南京大学模式动物研究所教授。2014年获江苏省杰出青年和江苏省双创人才。

代表性论文

1.     He XY, Li YJ, Kalyanaraman C, Qiu LL, Chen C, Xiao Q, Liu WX, Zhang W, Yang JJ, Chen G, Jacobson MP, Shi YS. (2016) GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. Proc Natl Acad Sci U S A. Sep 6; [Epub ahead of print]

2.     Wei M, Zhang J, Jia M, Yang C, Pan Y, Li S, Luo Y, Zheng J, Ji J, Chen J, Hu X, Xiong J, Shi Y, Zhang C.(2016) α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. Proc Natl Acad Sci U S A. May 10; 113(19):E2695-704.

3.     Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll RA. (2015) Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. Elife. pii: e11682

4.     Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013) LTP requires an extrasynaptic pool of glutamate receptors independent of subunit type. Nature. 493(7433)，495-500

5.     Herring B*, Shi Y*, Suh YH, Zheng CY, Schmid SM, Roche KW, Nicoll RA. (2013) Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 77(6),1083-96 *共同第一作者

6.     Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA. (2011) Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: analysis of single-cell GluN2 subunit deletion in vivo. Neuron. 71(6), 1085-1101

7.     Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll RA. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A. 107(37), 16315-16319

8.     Shi Y, Lu W, Milstein AD, Nicoll RA. (2009) The stoichiometry of AMPA receptors and TARPs varies by neuronal cell types. Neuron. 62(5), 633-40  

9.     Lu W, Shi Y, Jackson A, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron. 62(2), 254-68

10. Shi Y, Chen X, Wu Z, Shi W, Jiang C, Harrison R. (2008) cAMP-dependent protein kinase phosphorylation produces interdomain movements in SUR2B leading to activation of vascular K_ATP channel. Journal of Biological Chemistry. 283(12), 7523-30

11. Shi Y, Cui N, Shi W, Jiang C. (2008) A short motif in Kir6.1 consisting of 4 phosphorylation repeats underlies vascular K_ATP channel inhibition by protein kinase C. Journal of Biological Chemistry. 283(5), 2488-94

12. Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT, Jiang C. (2007) PKA phosphorylation on SUR2B subunit underscores vascular K_ATP channel activation by β-adrenergic receptors. American Journal of Physiology. 293(3), R1205-14