题 目：Molecular regulation of the late tooth development

时 间：2016年9月27日（星期二） 上午9:30-11:00

地 点：1号楼406室

报告人：EUI-SIC CHO（D.D.S.） PhD

Professor /Director

Laboratory for Craniofacial Biology

Cluster for Craniofacial Development and Regeneration Research

Chonbuk National University School of Dentistry

报告人简介：

      EUI-SIC CHO，教授，博士生导师。1989年，获韩国全北国立大学牙医学院（Chonbuk National University School of Dentistry）学士学位。1991年，获韩国全北国立大学硕士学位。1998年，获韩国全北国立大学博士学位。2000-2002年在美国罗切斯特大学学习。

1996-1998年，韩国全北国立大学牙医学院讲师；1998-2002年，韩国全北国立大学牙医学院助理教授；2002年至今，韩国全北国立大学牙医学院教授；2010-2012年，韩国全北国立大学口腔生物研究所所长、牙医学院副院长。

近五年代表性文章：

[1] Moon YJ, Yun CY, Choi H, Ka SO, Kim JR, Park BH, CHO ES (2016) Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability. Exp Mol Med. 2016 Sep 2;48(9):e256.

[2] Moon YJ, Yun CY, Lee JC, Kim JR, Park BH*, CHO ES* (2016) Maturation of cortical bone suppresses periosteal osteoprogenitor proliferation in a paracrine manner. J Mol Histol. 2016 Oct;47(5):445-53.

[3] Bae CH, Choi H, You HK, CHO ES (2016) Wnt activity is associated with cementum type transition. J Periodontal Res. 2016 Jul 1 [Epub ahead of print]

[4] Sim HJ, Kook SH, Yun CY, CHO ES*, Lee JC* (2016) Consecutive alendronate administration-mediated inhibition of osteoclasts improves long-term engraftment potential and stress resistance of HSCs. Stem Cells.2016 Jun 14. [Epub ahead of print]

[5] Kook SH, Yun CY, Sim HJ, Lee BC, Lee KY, CHO ES*, Lee JC* (2016) Smad4 in osteoblasts exerts differential impact on HSC fate in bone marrow microenvironment depending on osteoblast maturation stage. Leukemia. 2016 Jun 7 [Epub ahead of print]

[6] Yoo SH, Kim JG, Kim BS, Lee J, Pi SH, Lim HD, Shin HI, CHO ES, You HK (2016) BST2 mediates osteoblast differentiation via the BMP2 signaling pathway in human alveolar-derived bone marrow stromal cells. PLoS One 11(6):e0158481.

[7] Choi H, Ahn YH, Kim TH, Bae CH, Lee JC, You HK, CHO ES (2016) TGF-β signaling regulates cementum formation through Osterix expression. Sci Rep 6:26046.

[8] Choi H, Kim TH, Yun CY, Kim JW, CHO ES (2016) Testicular acid phosphatase induces odontoblast differentiation and mineralization. Cell Tissue Res 364(1):95-103.

[9] Lee SY, Yi JK, Yun HM, Bae CH, CHO ES, Lee KS, Kim EC (2016) Expression of Caveolin-1 in mouse periodontal tissue and its role in osteoblastic/cementoblastic differentiation in vitro. Calcif Tissue Int 98(5):497-510.

[10] Kook SH, Lee D, CHO ES, Heo JS, Poudel SB, Ahn YH, Hwang JW, Ji H, Kim JG, Lee JC (2016) Activation of canonical Wnt/β-catenin signaling inhibits H2O2-induced decreases in proliferation and differentiation of human periodontal ligament fibroblasts. Mol Cell Biochem 411(1):83-94.

[11] Lim SS, Kook SH, Bhattarai G, CHO ES, Seo YK, Lee JC (2015) Local delivery of COMP-angiopoietin 1 accelerates new bone formation in rat calvarial defects. J Biomed Mat Res Part A 103(9):2942-2951.

[12] Hong KY, Bae H, Park I, Park DY, Kim KH, Kubota Y, CHO ES, Kim H, Adams RH, Yoo OJ, Koh GY (2015) Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion. Development 142(15):2623-2632.

[13] Lee SI, Lee DW, Yun HM, Cha HJ, Bae CH, CHO ES, Kim EC (2015) Expression of thymosin beta-4 in human periodontal ligament cells and mouse periodontal tissue and its role in osteoblastic/cementoblastic differentiation. Differentiation 90(1-3):16-26.

[14] Kim TH, Bae CH, Yang S, Park JC, CHO ES (2015) Nfic regulates tooth root patterning and growth. Anat Cell Biol 48(3):188-194.

[15] CHO ES, Kim TH, Bae CH (2015) Response to letter to the editor in regard to: “Osterix regulates tooth root formation in a site-specific manner”. J Dent Res 94(9):1327.

[16] Ahn YH, Kim TH, Choi H, Bae CH, Yang YM, Baek JA, Lee JC, CHO ES (2015) Disruption of Tgfbr2 in odontoblast leads to aberrant pulp calcification. J Dent Res 94(6):828-835.

[17] Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, CHO ES (2015) Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun 459(4):706-712.

[18] Kim TH, Bae CH, Lee JC, Kim JE, Yang X, de Chrombrugghe B, CHO ES (2015) Osterix regulates tooth root formation in a site-specific manner. J Dent Res 94(3):430-438.

[19] Bae CH, Kim TH, Ko SO, Lee JC, Yang X, CHO ES (2015) Wntless regulates dentin apposition and root elongation in mandibular molar. J Dent Res 94(3):439-445.

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