刘阳课题组

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刘阳

来源 : 作者 : admin 时间 : 2011-12-01

刘阳教授

职务：PI

导师类别：硕士生导师

联系电话：(0571) 28867908

E-mail：yang_liu@idrbio.org; liuyangk@yahoo.com

研究方向：感觉神经元的发育调控、慢性痛形成机制

通讯地址：浙江省杭州市下沙高教园区学林街16号，310036

研究领域：

利用遗传学方法，研究痛/痒神经元的发育和功能的调控机制，及其在病理条件下发生改变的分子机理和途径，并在此基础上建立躯体/内脏慢性痛疾病的动物模型。

科研项目：

1. 国家自然科学基金面上项目（31171071）：Runx1在冷感受器TrpM8表达调控以及异常性冷痛产生中的作用研究，刘阳，2012.1-2015.12，56万元

发表文章：

1. Yang Liu and Qiufu Ma. Generation of somatic sensory neuron diversity and implication on sensory coding. Curr. Opin. Neurobiol. 2011 21(1):52-60.

2. Yang Liu*, Omar Abdel Samad*, Ling Zhang, Bo Duan, Qingchun Tong, Claudia Lopes, Ru-Rong Ji, Bradford B Lowell, and Qiufu Ma. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron. 2010 68(3):543-56. (* these authors contributed equally to this work)

3. Omar Abdel Samad*, Yang Liu*, Fu-Chia Yang*, Ina Kramer, Silvia Arber, and Qiufu Ma. Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain. Mol Pain. 2010 6:45. (* these authors contributed equally to this work)

4. Yang Liu, Fu-Chia Yang, Tsukasa Okuda, Xinzhong Dong, Mark J. Zylka, Chih-Li Chen, David J. Anderson, Rohini Kuner, and Qiufu Ma. Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci. 2008 28(1):125-32.

5. Chih-Li Chen*, Daniel Broom*, Yang Liu*, Joriene de Nooij, Zhe Li, Chuan Cen, Omar Abdel Samad, Thomas Jessell, Clifford Woolf and Qiufu Ma. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006 49(3):365-77. (* these authors contributed equally to this work)

6. Eduardo Gascon, Stephane Gaillard, Pascale Malapert, Yang Liu, Lise Rodat-Despoix, Igor Samokhvalov, Patrick Delmas, Francoise Helmbacher, Flavio Maina, and Aziz moqrich. HGF-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010 30(37):12414-12423.

7. Mingnan Liu, Yang Liu, Ying Liu, Giuseppe Lupo, Lei Lan, Giuseppina Barsacchi, and Rongqiao He. A role for Xvax2 in controlling proliferation of Xenopus ventral eye and brain progenitors. Dev Dyn. 2008 237(11):3387-93.

8. Marco Onorati, Federico Cremisi, Yang Liu, Rong-Qiao He, Giuseppina Barsacchi and Robert Vignali. A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina. Neural Develop. 2007 2:12.

9. Lei Lan, Mingnan Liu, Yang Liu, Ying Liu, Wei Zhang, Jinxiao Xue, Zhigang Xue, Rongqiao He. Expression of qBrn-1, a new member of the POU gene family, in the early developing nervous system and embryonic kidney. Dev Dyn. 2006 235(4):1107-14.

10. Paul Gray, Hui Fu, Ping Luo, Qing Zhao, Jing Yu, Annette Ferrari, Toyoaki Tenzen, Dong-in Yuk, Eric Tsung, Zhaohui Cai, John Alberta, Le-ping Cheng, Yang Liu, Jan Stenman, Todd Valerius, Nathan Billings, Haesun Kim, Michael Greenberg, Andrew McMahon, David Rowitch, Charles Stiles, Qiufu Ma. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 306(5705):2255-7.