陶艳梅课题组

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陶艳梅课题组

来源 : 作者 : admin 时间 : 2011-12-01

陶艳梅

陶艳梅教授

浙江省钱江学者特聘教授

联系电话：(0571)28867021

E-mail：taoyanmei@idrbio.org

研究方向：神经系统高级功能的分子调控机制

通讯地址：浙江省杭州市下沙高教园区学林街16号，杭州，310036

研究概述:

主要从事中枢神经系统神经元和胶质细胞发育及功能方面的研究。一、研究中枢神经系统晚期发育的关键分子机制。精神类疾病（psychiatric disorders）包括精神分裂症、双相障碍症、自闭症、抑郁症等多种脑高级功能失调的疾病，其本质是中枢神经系统晚期发育异常所致。我们着力于兴奋性突触形成和传递的细胞特异性分子调节机制，以及中枢髓鞘形成和维持的分子调节机制，为神经系统高级功能受损的疾病诸如精神类疾病提供理论基础和防治靶点。二、构建大脑高级功能失调动物模型。以转基因鼠和基因突变工程小鼠为主要模式生物，建立大脑高级功能（如认知、学习、记忆、情绪、社交能力等）失调的动物模型，以研究疑似致病基因的功能和分子机制，以及进一步筛选导致大脑高级功能失调的细胞特异性的关键因子和信号通路。

科研项目：

1. 国家自然科学基金面上项目（31271137）（主持人）：中枢髓鞘晚期发育的关键分子机制及其与精神性疾病相关性的研究，2013.01-2013.12，15万

2. 国家自然科学基金面上项目（31371075）（主持人）：ErbB信号通路调节精神分裂症病理病症发生的髓鞘机制研究，2014.01-2017.12，97万

代表性论文:

1. Y. Tao, C. Shen, S. Luo, W. Traore, S. Marchetto, M.-J. Santoni, L. Xu, C. Shi, J. Mei, R. Bates, X. Liu, K. Zhao, W.-C. Xiong, J.-P. Borg, L. Mei*, Role of Erbin in ErbB2-dependent breast tumor growth. Proc. Natl. Acad. Sci. U. S. A. doi/10.1073/pnas.1407139111, 2014.

2. Y. Tao, W.-C. Xiong, L. Mei*, Erbin in cortical inhibition. Future Neurology, 8(4):369-372, 2013.

3. Y. Tao*, Isolation and culture of Schwann cells. Neural Development: Methods in Molecular Biology, Vol 1018: 93-104, 2013.

4. Y. Tao, Y. Chen, C. Shen, Z. Luo, C.R. Bates, D. Lee, S. Marchetto, T. Gao, J. P. Borg, W. -C. Xiong, L. Mei*. Erbin interacts with TARP g-2 for surface expression of AMPA receptors in cortical interneurons. Nat. Neurosci. 16, 290-299, 2013.

5. C. Liang, Y. Tao*, C. Shen, W. -C. Xiong, L. Mei*. Erbin is required for axon regeneration and remyelination after nerve injury in adulthood. J. Neurosci. 32(43):15169-15180, 2012.

6. A. Ting, Y. Chen, L.Wen, D.-M. Yin, C. Shen, Y. Tao, X. Liu, W.-C. Xiong, L. Mei*. Neuregulin1 promotes excitatory synapse development specifically in GABAergic interneurons. J. Neurosci., 31(1):15-25, 2011.

7. Y. Tao, P. Dai, Y. Liu, W. -C. Xiong, J. P. Borg, L. Mei*. Erbin regulates neuregulin signaling and myelination. Proc. Natl. Acad. Sci. U. S. A.106(23):9477-9482, 2009. (FACULTY OF 1000 BIOLOGY recommended.)

8. S. Luo, B.Zhang, X.P. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C. Chiu, W. -C. Xiong, L. Mei*. HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron 60(1):97-110, 2008.

9. J. Arikkath, I. Israely, Y. Tao, L. Mei, X. Liu, L. F. Reichardt*. Erbin controls dendritic morphogenesis by regulating localization of delta-Catenin. J. Neurosci. 28(28), 7047-7056, 2008.

10. C. Brooks, Q. Wei, L. Feng, G. Dong, Y. Tao, L. Mei, Z.-J. Xie, D. C Chan, Z. Dong*. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with Mitofusins. Proc. Natl. Acad. Sci. U. S. A. 104(28):11649-11654, 2007.

11. R.-S. Woo, X.M. Li, Y. Tao, E Carpenter-Hyland, J. Wu, C. Lai, W.-C. Xiong, and L. Mei*. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54(4):599-610, 2007.

12. Y. Liu, Y. Tao, R.-S. Woo, W.-C. Xiong, and L. Mei*. Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons. Biochem. Biophys. Rapid Comm. 354(2):505-510, 2007.

13. Y. Tao, D. Yan, Q. Yang, R. Zeng, Y. Wang*. Low K⁺promotes NF-κB/DNA binding in neuronal apoptosis induced by K⁺ loss. Mol. Cell Biol. 26(3):1038-1050, 2006.

14. Y. Tao, R. Zeng, B. Shen, J. Jia, Y. Wang*. Neuronal transmission stimulates the phosphorylation of Kv1.4 channel at Ser229 through protein kinase A. J. Neurochem. 94(6):1512-1522, 2005.

15. Y. Tao*, W. Dong, S. Jia, X. Dai. Effect of ginkgo biloba extract (EGb761) on the changes of intracellular calcium concentration and mobility induced by amikacin in outer hair cell isolated from guinea pig cochlear. Chinese Journal of Pharmacology and Toxicology, 15(5):372-376, 2001.

16. Y. Tao*, J. Wu, Y. Wang, Z. Zhang, J. Wang, Z. Hu. Effects of low level laser irradiation on intracellular free calcium concentration and SOD activity in vitro and in vivo study. Applied Laser, 17(2):89-93, 1997.