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学术讲座通知（2013年11月14日上午10:00，美国哈佛大学医学院Charles D. Stiles教授）
作者：admin 发布时间：2013-11-08 10:52:35 浏览：142 次
报告题目：Conflict of Interest: An Oppositional Relationship Between Stemness and p53 in Malignant Glioma
报告人：Charles D. Stiles, Ph.D.
报告时间：2013年11月14日（星期四）上午10:00
地点：行政楼叙伦厅
个人简介
Charles Stiles，哈佛大学医学院神经生物学系教授，Dana-Farber癌症研究所癌症生物学系系主任。1968年毕业于美国加州大学，获微生物学学士学位，1973年毕业于美国田纳西大学，获生物化学博士学位。1973-1976 年，在美国加州大学生物系从事博士后研究工作；1976-1980 年，哈佛大学医学院微生物学与分子遗传学系、Dana-Farber 癌症研究所癌症生物系，助理教授；1980-1986年，哈佛大学医学院微生物学与分子遗传学系、Dana-Farber 癌症研究所癌症生物系，副教授；1986-2011年，哈佛大学医学院微生物学与分子遗传学系和Dana-Farber 癌症研究所，教授；2007年，哈佛大学医学院神经外科系和Brigham 妇女医院，兼职教授；2011-至今，哈佛大学医学院神经生物学系和Dana-Farber 癌症研究所，教授。已发表SCI论文127篇，出版专著（包括专题讨论会）28部，授权发明专利6项。欢迎广大师生积极踊跃参加！
Current Research Activities：
Our major research interests are in the areas of neural stem cells, transcription factors, and signal transduction as applied to brain development. Under auspices of the research support package outlined above, my students and I are defining the molecular and genetic mechanisms that regulate the development of normal brain from multipotent brain progenitor cells. We believe that fundamental insights into the molecular biology of normal brain development will have practical overtones for the treatment of primary central nervous system cancers.
Publications：
1. Kenney FT, Lee KL, Stiles CD and Fritz JE. Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol. 1973; 246: 208-10.
2. Stiles CD, Desmond W, Jr., Sato G and Saier MH, Jr. Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice. Proc Natl Acad Sci U S A. 1975; 72: 4971-5.
3. Stiles CD, Desmond W, Chuman LM, Sato G and Saier MH, Jr. Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Res. 1976; 36: 3300-5.
4. Stiles CD, Desmond W, Chuman LM, Sato G and Saier MH. Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse. Cancer Res. 1976; 36: 1353-60.
5. Stiles CD, Lee KL and Kenney FT. Differential degradation of messenger RNAs in mammalian cells. Proc Natl Acad Sci U S A. 1976; 73: 2634-8.
6. Pledger WJ, Stiles CD, Antoniades HN and Scher CD. Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci U S A. 1977; 74: 4481-5.
7. Pledger WJ, Stiles CD, Antoniades HN and Scher CD. An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis. Proc Natl Acad Sci U S A. 1978; 75: 2839-43.
8. Scher CD, Pledger WJ, Martin P, Antoniades H and Stiles CD. Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor. J Cell Physiol. 1978; 97: 371-80.
9. Antoniades HN, Scher CD and Stiles CD. Purification of human platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979; 76: 1809-13.
10. Frantz CN, Stiles CD and Scher CD. The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors. J Cell Physiol. 1979; 100: 413-24.
11. Kaplan DR, Chao FC, Stiles CD, Antoniades HN and Scher CD. Platelet alpha granules contain a growth factor for fibroblasts. Blood. 1979; 53: 1043-52.
12. Reid LM, Stiles CD, Saier MH, Jr. and Rindler MJ. Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation. Cancer Res. 1979; 39: 1467-73.
13. Stiles CD, Capone GT, Scher CD, Antoniades HN, Van Wyk JJ and Pledger WJ. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979; 76: 1279-83.
14. Stiles CD, Isberg RR, Pledger WJ, Antoniades HN and Scher CD. Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma. J Cell Physiol. 1979; 99: 395-405.
15. Tucker RW, Scher CD and Stiles CD. Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40. Cell. 1979; 18: 1065-72.
16. Frantz CN, Stiles CD, Pledger WJ and Scher CD. Effect of ouabain on growth regulation by serum components in Balb/c-3T3 cells: inhibition of entry into S phase by decreased protein synthesis. J Cell Physiol. 1980; 105: 439-48.
17. Cochran BH, Lillquist JS and Stiles CD. Post-transcriptional control of protein synthesis in Balb/c-3T3 cells by platelet-derived growth factor and platelet-poor plasma. J Cell Physiol. 1981; 109: 429-38.
18. Smith JC and Stiles CD. Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor. Proc Natl Acad Sci U S A. 1981; 78: 4363-7.
19. Singh JP, Chaikin MA and Stiles CD. Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J Cell Biol. 1982; 95: 667-71.
20. Smith JC, Singh JP, Lillquist JS, Goon DS and Stiles CD. Growth factors adherent to cell substrate are mitogenically active in situ. Nature. 1982; 296: 154-6.
21. Cochran BH, Reffel AC and Stiles CD. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983; 33: 939-47.
22. Kelly K, Cochran BH, Stiles CD and Leder P. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell. 1983; 35: 603-10.
23. Singh JP, Chaikin MA, Pledger WJ, Scher CD and Stiles CD. Persistence of the mitogenic response to platelet-derived growth factor (competence) does not reflect a long-term interaction between the growth factor and the target cell. J Cell Biol. 1983; 96: 1497-502.
24. Stiles CD. The molecular biology of platelet-derived growth factor. Cell. 1983; 33: 653-5.
25. Armelin HA, Armelin MC, Kelly K, Stewart T, Leder P, Cochran BH and Stiles CD. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature. 1984; 310: 655-60.
26. Bockus BJ and Stiles CD. Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor. Exp Cell Res. 1984; 153: 186-97.
27. Cochran BH, Zullo J, Verma IM and Stiles CD. Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science. 1984; 226: 1080-2.
28. Stiles CD. Autocrine control of growth? Nature. 1984; 311: 604-5.
29. Stiles CD. The biological role of oncogenes--insights from platelet-derived growth factor: Rhoads Memorial Award lecture. Cancer Res. 1985; 45: 5215-8.
30. Zullo JN, Cochran BH, Huang AS and Stiles CD. Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells. Cell. 1985; 43: 793-800.
31. Gibson CW, Rittling SR, Hirschhorn RR, Kaczmarek L, Calabretta B, Stiles CD and Baserga R. Cell cycle dependent genes inducible by different mitogens in cells from different species. Mol Cell Biochem. 1986; 71: 61-9.
32. Hall DJ and Stiles CD. Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers. J Biol Chem. 1987; 262: 15302-8.
33. Rollins BJ, Morrison ED and Stiles CD. A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor. Science. 1987; 238: 1269-71.
34. Zullo J, Stiles CD and Garcea RL. Regulation of c-myc and c-fos mRNA levels by polyomavirus: distinct roles for the capsid protein VP1 and the viral early proteins. Proc Natl Acad Sci U S A. 1987; 84: 1210-4.
35. Zumstein P and Stiles CD. Molecular cloning of gene sequences that are regulated by insulin-like growth factor I. J Biol Chem. 1987; 262: 11252-60.
36. Mercola M, Melton DA and Stiles CD. Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos. Science. 1988; 241: 1223-5.
37. Rollins BJ, Morrison ED and Stiles CD. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci U S A. 1988; 85: 3738-42.
38. Rollins BJ and Stiles CD. Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors. In Vitro Cell Dev Biol. 1988; 24: 81-4.
39. Garcia-Blanco MA, Lengyel P, Morrison E, Brownlee C, Stiles CD, Rutherford M, Hannigan G and Williams BR. Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor. Mol Cell Biol. 1989; 9: 1060-8.
40. Hall DJ, Alberta JA and Stiles CD. Labile repressors are involved in the transcriptional control of PDGF-responsive genes. Oncogene Res. 1989; 4: 177-84.
41. Hall DJ, Brownlee C and Stiles CD. Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts. J Cell Physiol. 1989; 141: 154-9.
42. Hall DJ, Jones SD, Kaplan DR, Whitman M, Rollins BJ and Stiles CD. Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA. Mol Cell Biol. 1989; 9: 1705-13.
43. Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R and Stiles CD. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989; 264: 4133-7.
44. Rollins BJ, O'Connell TM, Bennett G, Burton LE, Stiles CD and Rheinwald JG. Environment-dependent growth inhibition of human epidermal keratinocytes by recombinant human transforming growth factor-beta. J Cell Physiol. 1989; 139: 455-62.
45. Garcia-Blanco MA, Porter JA, Morrison ED and Stiles CD. The beta-interferon-mediated antimitogenic state resembles the anti-viral state. Oncogene Res. 1990; 5: 323-8.
46. Mercola M, Deininger PL, Shamah SM, Porter J, Wang CY and Stiles CD. Dominant-negative mutants of a platelet-derived growth factor gene. Genes Dev. 1990; 4: 2333-41.
47. Mercola M, Wang CY, Kelly J, Brownlee C, Jackson-Grusby L, Stiles C and Bowen-Pope D. Selective expression of PDGF A and its receptor during early mouse embryogenesis. Dev Biol. 1990; 138: 114-22.
48. Wang C, Kelly J, Bowen-Pope DF and Stiles CD. Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. Mol Cell Biol. 1990; 10: 6781-4.
49. Stephenson DA, Mercola M, Anderson E, Wang CY, Stiles CD, Bowen-Pope DF and Chapman VM. Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A. 1991; 88: 6-10.
50. Yaeger PC, Stiles CD and Rollins BJ. Human keratinocyte growth-promoting activity on the surface of fibroblasts. J Cell Physiol. 1991; 149: 110-6.
51. Epstein RJ, Druker BJ, Irminger JC, Jones SD, Roberts TM and Stiles CD. Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. Cell Growth Differ. 1992; 3: 157-64.
52. Epstein RJ, Druker BJ, Roberts TM and Stiles CD. Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. 1992; 89: 10435-9.
53. Freter RR, Irminger JC, Porter JA, Jones SD and Stiles CD. A novel 7-nucleotide motif located in 3' untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the JE gene. Mol Cell Biol. 1992; 12: 5288-300.
54. Palmieri SL, Payne J, Stiles CD, Biggers JD and Mercola M. Expression of mouse PDGF-A and PDGF alpha-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action. Mech Dev. 1992; 39: 181-91.
55. Wang C, Shamah SM and Stiles CD. Recombinant PDGF from lower vertebrates: receptor binding and immunochemical analysis with metabolically labeled growth factor. Growth Factors. 1992; 7: 279-88.
56. Jones SD, Ho L, Smith JC, Yordan C, Stiles CD and Mercola M. The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression. Dev Genet. 1993; 14: 185-93.
57. Mudhar HS, Pollock RA, Wang C, Stiles CD and Richardson WD. PDGF and its receptors in the developing rodent retina and optic nerve. Development. 1993; 118: 539-52.
58. Shamah SM, Stiles CD and Guha A. Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol. 1993; 13: 7203-12.
59. Wang C and Stiles CD. Regulation of platelet-derived growth factor A messenger RNA translation in differentiating F9 teratocarcinoma cells. Cell Growth Differ. 1993; 4: 871-7.
60. Alberta JA, Rundell K and Stiles CD. Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J Biol Chem. 1994; 269: 4532-8.
61. Segal RA, Goumnerova LC, Kwon YK, Stiles CD and Pomeroy SL. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci U S A. 1994; 91: 12867-71.
62. Wang C and Stiles CD. Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements. Proc Natl Acad Sci U S A. 1994; 91: 7061-5.
63. Freter RR, Alberta JA, Lam KK and Stiles CD. A new platelet-derived growth factor-regulated genomic element which binds a serine/threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1. Mol Cell Biol. 1995; 15: 315-25.
64. Guha A, Dashner K, Black PM, Wagner JA and Stiles CD. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer. 1995; 60: 168-73.
65. Guha A, Glowacka D, Carroll R, Dashner K, Black PM and Stiles CD. Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome. J Neurol Neurosurg Psychiatry. 1995; 58: 711-4.
66. Segal RA, Pomeroy SL and Stiles CD. Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci. 1995; 15: 4970-81.
67. Freter RR, Alberta JA, Hwang GY, Wrentmore AL and Stiles CD. Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappaB and a 90-kDa phosphoprotein coactivator. J Biol Chem. 1996; 271: 17417-24.
68. Segal RA, Bhattacharyya A, Rua LA, Alberta JA, Stephens RM, Kaplan DR and Stiles CD. Differential utilization of Trk autophosphorylation sites. J Biol Chem. 1996; 271: 20175-81.
69. Alberta JA and Stiles CD. Phosphorylation-directed antibodies in high-flux screens for compounds that modulate signal transduction. Biotechniques. 1997; 23: 490-3.
70. Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD and Segal RA. Trk receptors function as rapid retrograde signal carriers in the adult nervous system. J Neurosci. 1997; 17: 7007-16.
71. Kwon YK, Bhattacharyya A, Alberta JA, Giannobile WV, Cheon K, Stiles CD and Pomeroy SL. Activation of ErbB2 during wallerian degeneration of sciatic nerve. J Neurosci. 1997; 17: 8293-9.
72. Reinertsen KK, Bronson RT, Stiles CD and Wang C. Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice. Gene Expr. 1997; 6: 301-14.
73. Shamah SM, Alberta JA, Giannobile WV, Guha A, Kwon YK, Carroll RS, Black PM and Stiles CD. Detection of activated platelet-derived growth factor receptors in human meningioma. Cancer Res. 1997; 57: 4141-7.
74. Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, Roberts TM and Stiles CD. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron. 1997; 18: 553-62.
75. Alberta JA, Auger KR, Batt D, Iannarelli P, Hwang G, Elliott HL, Duke R, Roberts TM and Stiles CD. Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem. 1999; 274: 31062-7.
76. Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C and Eng C. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet. 1999; 8: 185-93.
77. Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA and Pomeroy SL. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res. 1999; 59: 711-9.
78. Park JK, Williams BP, Alberta JA and Stiles CD. Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J Neurosci. 1999; 19: 10383-9.
79. Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD and Segal RA. TrkA glycosylation regulates receptor localization and activity. J Neurobiol. 1999; 39: 323-36.
80. Kilic T*, Alberta JA*, Zdunek PR, Acar M, Iannarelli P, O'Reilly T, Buchdunger E, Black PM and Stiles CD. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 2000; 60: 5143-50. *equal authorship
81. Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD and Roberts TM. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000; 26: 405-16.
82. Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD and Rowitch DH. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000; 25: 317-29.
83. Wang WL, Healy ME, Sattler M, Verma S, Lin J, Maulik G, Stiles CD, Griffin JD, Johnson BE and Salgia R. Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571. Oncogene. 2000; 19: 3521-8.
84. Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD and Rowitch DH. Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci. 2001; 18: 434-41.
85. Kim HA, Ratner N, Roberts TM and Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci. 2001; 21: 1110-6.
86. Lu QR, Cai L, Rowitch D, Cepko CL and Stiles CD. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci. 2001; 4: 973-4.
87. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH and Black PM. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci U S A. 2001; 98: 10851-6.
88. Sun T, Echelard Y, Lu R, Yuk DI, Kaing S, Stiles CD and Rowitch DH. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol. 2001; 11: 1413-20.
89. Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH and Richardson WD. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development. 2001; 128: 2545-54.
90. Woodruff RH, Tekki-Kessaris N, Stiles CD, Rowitch DH and Richardson WD. Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives. Int J Dev Neurosci. 2001; 19: 379-85.
91. Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD and Segal RA. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J Neurobiol. 2002; 51: 302-12.
92. Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD and Rowitch DH. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002; 109: 75-86.
93. Sauvageot CM and Stiles CD. Molecular mechanisms controlling cortical gliogenesis. Curr Opin Neurobiol. 2002; 12: 244-9.
94. Bithell A, Alberta J, Hornby F, Stiles CD and Williams BP. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Res Dev Brain Res. 2003; 146: 107-18.
95. Ross SE, Greenberg ME and Stiles CD. Basic helix-loop-helix factors in cortical development. Neuron. 2003; 39: 13-25.
96. Stiles CD. Lost in space: misregulated positional cues create tripotent neural progenitors in cell culture. Neuron. 2003; 40: 447-9.
97. Sun T*, Dong H*, Wu L, Kane M, Rowitch DH and Stiles CD. Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci. 2003; 23: 9547-56. *equal authorship
98. Arnett HA*, Fancy SP*, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ and Stiles CD. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004; 306: 2111-5. *equal authorship
99. Gray PA*, Fu H*, Luo P*, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD and Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004; 306: 2255-7. *equal authorship
100. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD and Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004; 63: 499-509.
101. Dahia PL, Hao K, Rogus J, Colin C, Pujana MA, Ross K, Magoffin D, Aronin N, Cascon A, Hayashida CY, Li C, Toledo SP and Stiles CD. Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res. 2005; 65: 9651-8.
102. Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C and Stiles CD. A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet. 2005; 1: 72-80.
103. Kesari S, Ramakrishna N, Sauvageot C, Stiles CD and Wen PY. Targeted molecular therapy of malignant gliomas. Curr Neurol Neurosci Rep. 2005; 5: 186-97.
104. McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005; 5: 14.
105. Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA and Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J Neurobiol. 2005; 62: 121-33.
106. Kesari S, Ramakrishna N, Sauvageot C, Stiles CD and Wen PY. Targeted molecular therapy of malignant gliomas. Curr Oncol Rep. 2006; 8: 58-70.
107. Kesari S and Stiles CD. The bad seed: PDGF receptors link adult neural progenitors to glioma stem cells. Neuron. 2006; 51: 151-3.
108. Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD and Rowitch DH. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 2006; 103: 7853-8.
109. Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD and Rowitch DH. Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol. 2006; 292: 152-64.
110. Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, Abrey LE, Raizer J, Cloughesy TF, Fink K, Gilbert M, Chang S, Junck L, Schiff D, Lieberman F, Fine HA, Mehta M, Robins HI, DeAngelis LM, Groves MD, Puduvalli VK, Levin V, Conrad C, Maher EA, Aldape K, Hayes M, Letvak L, Egorin MJ, Capdeville R, Kaplan R, Murgo AJ, Stiles C and Prados MD. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res. 2006; 12: 4899-907.
111. Kesari S, Jackson-Grusby L and Stiles CD. "Smad"eningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma. Dev Cell. 2007; 12: 324-5.
112. Ligon KL*, Huillard E*, Mehta S*, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD and Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007; 53: 503-17. *equal authorship
113. Sauvageot CM, Kesari S and Stiles CD. Molecular pathogenesis of adult brain tumors and the role of stem cells. Neurol Clin. 2007; 25: 891-924, vii.
114. Kesari S, Jackson-Grusby L and Stiles CD. "Smad"eningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma. Dev Cell 2007; 12, 324-5.
115. Stiles CD and Rowitch DH. Glioma stem cells: a midterm exam. Neuron 2008; 58, 832-46.
116. Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM and Stiles CD. A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci 2009; 29, 11399-408.
117. MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML and Garraway LA. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One 2009; 4, e7887.
118. Sauvageot CM, Weatherbee JL, Kesari S, Winters SE, Barnes J, Dellagatta J, Ramakrishna NR, Stiles CD, Kung AL, Kieran MW and Wen PY. Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol 2009; 11, 109-21.
119. Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, Ligon KL, Aldape K, Jain RK, Stiles CD, Egorin MJ & Prados MD. Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro Oncol 2009; 11:853-60.
120. Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, and Dahia PL. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Nat Genet 2010; 42:229-33.
121. Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov;13(6):669-77. Epub 2011 Aug 30.
122. Gutmann DH, Stiles CD, Lowe SW, Bollag GE, Furnari FB, Charest AL. Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro Oncol. 2011 Jul;13(7):692-9. Review.
123. Mehta S*, Huillard E*, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF. Theisen M, Ligon KL, Rowitch DH, and Stiles CD. The CNS-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell 2011; 19: 359-371. (*equal authorship)
124. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien A-C, Fu H, Petryniak, M, Potter G, Liu Z, Powers JF, Runquist IS, Rowitch DH, and Stiles CD. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron 2011; 69: 906-917.
125. Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP. Development 2012; 139(10):1863-73.
126. Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ. Prospective, high-throughput molecular profiling of human gliomas. J Neurooncol 2012; 110(1):89-98. Epub 2012 Jul 22.
127. Zhou J, Stiles CD. Asleep at the Switch: MEK Kinases Control Transit to Gliogenesis in Developing Cortex. Neuron 2012; 75(6):940-2.
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