导师队伍

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【甘霖】

甘霖

 

 

甘霖 教授 

职        务:国家第五批“千人计划”入选者,国家特聘专家
导师类别:硕导、博导(浙江大学)
联系电话:(0571)28861419
E-mail:lin_gan@idrbio.org
研究方向:视觉神经系统的发育调控机制和相关疾病研究
通讯地址:浙江省杭州市下沙高教园区学林街16号,310036
 

 教育经历:

1981.9-1985.7 中山大学生物化学专业学士
1985.8-1986.8 上海生物化学研究所首届免试硕士研究生
1986.9-1987.5 美国俄亥厄州医学院博士研究生
1987.8-1992.11 美国德克萨斯大学(休斯顿)生物医学科学研究生院(University of Texas Graduate School of Biomedical Sciences) 博士(Ph.D.)
1992.12-1994.12 德克萨斯大学安德森癌症中心 (University of Texas-M.D, Anderson Cancer Center) 博士后
1994.8: 美国国家卫生部国家视觉研究所(NIH-NEI),海洋生物学实验室(Marine Biological Laboratory)Woods Hole, 马里兰州
 
工作经历:
1996.1-1996.8 美国德克萨斯大学安德森癌症中心(University of Texas-M.D. Anderson Cancer Center )生化与分子生物学系讲师 (Instructor)
1996.9-1999.8 美国德克萨斯大学安德森癌症中心转基因动物中心主任(
1999.9-2005.4 美国罗切斯特大学(University of Rochester) 神经生物学与解剖学系,衰老与发育中心,助理教授
2005.5-2009.6 美国罗切斯特大学眼科系,神经生物学与解剖学系,衰老与发育研究中心,终身副教授(Tenured Associate Professor)
2009.7-至美国罗切斯特大学眼科系,神经生物学与解剖学系,神经发育与疾病研究中心,终身教授(Tenured Professor)
2005.5-至今美国罗切斯特大学De Stephano视网膜基因组实验室主任
2006.9-至今美国罗切斯特大学转基因动物中心主任
2009.7-至今美国罗切斯特大学Flaum眼睛研究所研究所长(Director of Research, Flaum Eye Institute)
2009.11-至今美国罗切斯特大学院长讲席教授(Dean’s Professor Endowed Professor/Chair)
2011.3 - 至今杭州师范大学生命与环境科学院教授
 
主要成绩:
2011年中组部第五批千人计划A类),国家特聘专家
2011年美国防失明研究基金会资深科研者奖(Research to Prevent Blindness Senior Scientific Investigator Award)
1999年美国席伯尔曼学者奖(Rosanne H. Silbermann Fellow Award)
1994.8 National Eye Institute Fellowship for Fundamental Issues in Vision Research-Summer Training Program in MBL
中美生物化学联合招生项目,China-United States Biochemistry and Molecular Biology Examination and Administration Program (简称CUSBEA项目)
 
研究领域:
主要从事视觉神经系统的发育调控机制和相关疾病研究工作。
 
近五年领导(参与)过的主要项目:
1.         国家自然科学基金面上项目(81271006)(主持人):POU4F2 ISL1 转录因子在青光眼中的保护功能,2013.01-2016.12,¥700,000
2.         杭州市医疗卫生科研项目(20120633B01):Math5调控通道在视网膜发育中的功能及其与视神经疾病的关系,2013.01-2015.12,¥10,000
3.         美国国家卫生部研究基金 (NIH-NIDCD 1 RO1 DC008856), 主持人 (PI)“Function of LIM-domain Transcriptional Regulators in Inner Ear Development”03/01/08-04/30/13$1,636,250
4.         美国国家卫生部研究基金 (NIH-NEI 2 RO1 EY013426), 主持人 “Function of Math5 in Retinal Development”05/01/01-11/30/11$2,926,625
5.         2011年美国防失明研究基金会 (Research to Prevent Blindness)“Neural protection in glaucoma”01/01/11-12/31/11$75,000
6.         美国 ChemoCentryx 公司研究基金, 主持人,“Generation of humanized rodent model systems of cytokine receptors”09/05/05-06/30/11$287,400
7.         美国国家卫生部研究基金 (NIH-NIDCD 1 RO1 DC009250), Co-主持人 “Sensory Organ Formation in the Inner Ear”12/05/08-11/30/13$1,636,250
8.         美国国家卫生部研究基金 (NIH-NEI 5 RO1 EY015551), 主持人,“Brn3b Transcription Factors in Retinal Development”05/01/04-04/30/09$1,560,000
9.         美国国家卫生部研究基金 (NIH-NIDCD 1 RO1 HL070077), Co-主持人,“Analysis of a Retinoid-Induced Tumor Suppressor in SMC”07/01/03-06/30/07 $1,788,128
 
科研基金评审成员:
1.         美国罗切斯特大学基金评审委员会成员 (2002-present)
2.         美国-以色列科学基金 (United States-Israel Binational Science Foundation, BSF) (2003)
3.         美国老年研究基金 (American Federation for Aging Research, AFAR) (2004)
4.         英国 Wellcome 基金 (The Wellcome Trust) (2003-present)
5.         英国医学科学部基金 (The Medical Research Council) (2004-present)
6.         美国国家自然科学基金 (National Science Foundation Neural Systems Cluster) (2009.4)
7.         以色列科学基金 (Israel Science Foundation) (2010.3)
8.         美国国家卫生部 (NIH Study Sections): NDPR (Neural Differentiation, Plasticity, and Regeneration) Study Section (2006.2), NIH BDPE (Biology and Diseases of the Posterior Eye) Study Section (2008.6, 2009.2, 2009.6), NIH ZRG1 CB-G 02 S (Retinopathy Models and Therapy) Study Section (2009.6), NIH NCF (Neurogenesis and Cell Fate) Study Section (2009.10), NIH ZRG1 CB-G 90 (Retinopathy Models and Therapy) Study Section (2010.2), ZRG1-IFCN-B-02M (Auditory Neuroscience) Study Section (2010.10)
 
学术杂志审稿成员:
Brain Research, BMC Genetics, Development, Developmental Biology, Developmental Dynamics, Developmental Neurobiology, Genes & Development, Genesis, Hearing Research, Investigative Ophthalmology and Visual Science (IOVS), Journal of Biological Chemistry, Journal of Neurochemistry, Journal of Neuroscience, Journal of Neuroscience Research, Mechanism of Development, Molecular Vision, Nature Neuroscience, Neuroscience, Nucleic Acids Research, Ophthalmic Research, Vision Neuroscience
 
学术杂志编委:
Editorial Board, The Journal of Biological Chemistry (2010-2015)
 
代表性论文:
1.         Gan, L., Zhang, W., and Klein, W.H. (1990). Repetitive DNA sequences linked to the sea urchin Spec genes contain transcriptional enhancer-like elements. Dev. Biol. 139, 186-196.
2.         Gan, L., Wessel, G.M., and Klein, W.H. (1990). Regulatory elements from the related Spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene. Dev. Biol. 142, 346-358. (杂志封面).
3.         Klein, W.H., Tomlinson, C.R., Zhang, W., Xiang, M., Kozlowski, M.T., Gan, L., Nguyen, T., and Wessel, G.M. (1990). Ectoderm differentiation and the Spec gene family of sea urchin. In Developmental biology, UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 125, 123-134.
4.         Kozlowski, M.T., Gan, L., Venuti, J.M., Sawadogo, M., and Klein, W.H. (1991). Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells. Dev. Biol. 148, 625-630.
5.         Venuti, J.M., Gan, L., Kozlowski, M.T., and Klein, W.H. (1993). Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo. Mech. Dev. 41, 3-14. (杂志封面).
6.         Gan, L. and Klein, W.H. (1993). A positive cis -regulatory element with a bicoid -target site lies within the sea urchin Spec2a enhancer. Dev. Biol. 157,119-132.
7.         Mao, C-A., Gan, L., and Klein, W.H. (1994). Multiple Otx-binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene, Dev. Biol. 165, 229-242.
8.         Gan, L., Mao, C-A., Wikramanayake, A.H., Angerer, L.M., Angerer, R.C., and Klein, W.H. (1995). An orthodenticle-related protein from Strongylocentrotus purpuratus. Dev. Biol. 167, 517-528.
9.         Mao, C-A., Wikramanayake, A.H., Gan, L., Chuang, C-K., and Klein, W.H. (1996). Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein. Development 122, 1489-1498.
10.     Gan, L., Xiang, M., Zhou, L., Wagner, D.S., Klein, W.H., and Nathans, J. (1996). POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. 93, 3920-3925.
11.     Xiang, M.*, Gan, L.*, Zhou, L., Klein, W.H., and Nathans, J. (1996). Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired sucking. Proc. Natl. Acad. Sci. 93, 11950-11955. (*equal contribution)
12.     Klein, W.H., Mao, C-A., Gan, L., Chuang, C-K., and Wikramanayake, A.H. (1997). Manipulating cell fates in the sea urchin embryo. In Invertebrate Reproduction and Development 31:1-3, 21-29.
13.     Xiang, M., Gan, L., Li, D., Zhou, L., Chen, Z., Wagner, D., O'Malley Jr., B.W., Klein, W., and Nathans, J. (1997). Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. In Cold Spring Harbor Symposium on Quantitative Biology, Vol. LXII, 325-336.
14.     Xiang, M.*, Gan, L.*, Li, D.*, Chen, Z., Zhou, L., O'Malley Jr., B.W., Klein, W, and Nathans, J. (1997). Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc. Natl. Acad. Sci. 94, 9445-9450. (*equal contribution)
15.     Chen, H., Lun, Y., Ochinnikov, D., Kokubo, H., Oberg, K. C., Pepiclli, C. V., Gan, L., Lee, B., and Johnson, R.J. (1998). Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella symdrome. Nature Genetics 19, 51-55.
16.     Evrard, Y.A., Lun, Y., Aulehla, A., Gan, L. and Johnson, R.L. (1998). Lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394, 377-381.
17.     Wagner, D.S., Gan, L., and Klein, W.H. (1998). Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: Evidence for alternative rRNA production in hematopoietic cells. Biochem. Biophys. Res. Commun. 250, 674-681.
18.     Lin, X., Gan, L., Klein, W.H., and Wells, D. (1998). Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem. Biophys. Res. Commun. 248:738-743.
19.     Vivian, J.L., Gan, L., Olson, E.N., and Klein, W.H. (1999). Threshold levels of myogenin required for viability, skeletal muscle differentiation, and sternum formation revealed through a hypomorphic myogenin allele. Dev. Biol. 208, 44-55.
20.     Gan, L.*, Wang, S.W., Huang, Z., and Klein, W.H.* (1999). POU-domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification or migration. Dev. Biol. 210, 469-480. (*Co-corresponding)
21.     Wagner, D.S., Gan, L., and Klein, W.H. (1999). Identification of a differentially expressed RNA helicase by gene trapping. Biochem. Biophys. Res. Commun. 262, 677-684.
22.     Wang, S.W., Gan, L., Martin, S.E., and Klein, W.H. (2000). Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b. Mol. Cell. Neurosci. 16, 141-156. (杂志封面).
23.     Lu, J., Chang, P., Richardson, J.A., Gan, L., Weiler, H., Olson, E.N. (2000). The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proc. Natl. Acad. Sci. USA. 97, 9525-9530.
24.     Eng, S.R., Gratwick, K., Rhee, J.M., Fedtsova, N., Gan, L., and Turner, E.E. (2001). Defects in sensory axon guidance precede neuronal death in brn-3a-deficient mice. J. Neurosci. 21, 541-549.
25.     Wang, S.W., Kim, B.S., Ding, K., Wang, H., Sun, D., Johnson, R.L, Klein, W.H. and Gan, L. (2001). Requirement of math5 in the development of retinal ganglion cells. Genes & Dev. 15, 24-29.
26.     Kim, B.S., Savinova, O.V., Reedy, M.V., Martin, J., Lun, Y., Gan, L., Smith, R.S., Tomarev, S.I., John, S.W., and Johnson, R.L. (2001) Targeted disruption of the myocilin gene (Myoc) suggests that human glaucoma-causing mutations are gain of function. Mol. Cell. Biol. 21, 7707-7713.
27.     Mu, X., Zhao, S., Pershad, R., Tzung-Fu Hsieh, T-F., Scarpa, A., Wang, S.W., White, R.A., Thomas, T.L., Gan, L., and Klein, W.H. (2001). Analysis of the Transcriptome for the Developing Mouse Retina. Nucleic Acids Res. 24, 4983-4993.
28.     Wang, S.W., Mu, X., Bowers, W.J, Kim, D.S., Plas, D.J., Crair, M.C., Federoff, H.J., Gan, L., and Klein, W.H. (2001). Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 129, 467-77.
29.     Guo, Z., Clydesdale, G., Cheng, J., Kim, K., Gan, L., McConkey, D.J., Ullrich, S.E., Zhuang, Y., and Su, B. (2002). Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol. Cell. Biol. 22, 5761-5768.
30.     Yeh, S., Tsai, M.Y., Xu, Q., Mu, X.M., Lardy, H., Huang, K.E., Lin, H., Yeh, S.D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B.F., Hung, M.C., Zhang, S., Gan, L., and Chang, C. (2002). Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc. Natl. Acad. Sci. USA99, 13498-13503.
31.     Wee, R., Castrucci, A.M., Provencio, I., Gan, L., Van Gelder, R.N. (2002). Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. J Neurosci. 22, 10427-10433.
32.     Lu, J., Bassel-Duby, R., Hawkins, A., Chang, P., Valdez, R., Wu, H., Gan, L., Shelton, J.M., Richardson, J.A., and Olson, E.N. (2002). Control of facial muscle development by MyoR and Capsulin. Science 298, 2378-2381.
33.     Yang, Z., Ding, K., Pan, L., Deng, M., and Gan, L.. (2003). Math5 determines the competence state of retinal ganglion cell progenitors. Dev. Biol. 264, 240-254.
34.     Yan, D.-H., Wen, Y., Su, L.-K., Xia, W., Wang, S.-C., Zhang, S., Gan, L., Lee, D.-F., Frey J. A., Hortobagyi, G. N. and Hung, M.-C. (2004). A delayed chemically-induced tumorigenesis in Brca2 mutant mice. Oncogene 23, 1896-1901.
35.     Radde-Gallwitz, K., Pan, L., Gan, L., Lin, X., Segil, N., and Chen, P. (2004). Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J. Comp. Neurol. 477, 412-421. 36. Pan, L., Yang, Z., Feng, L., and Gan, L. (2005). Functional Equivalence of Brn-3 POU-Domain Transcription Factors in Mouse Retinal Neurogenesis. Development 132, 703-712. (杂志封面).
36.     Xie, J., Lu, L., Deng, M., Weng, S., Zhu, J., Wu, Y., Gan, L., Chan, S.M., and He, J. (2005). Inhibition of reporter gene and Iridovirus-tiger frog virus in fish cell by RNA interference. Virology 338, 43-52.
37.     Deng, M., Pan, L., Xie, X., and Gan, L. (2006). Differential Expression of LIM Domain-Only (LMO) Genes in the Developing Mouse Inner Ear. Gene Expr. Patterns 6, 857-863.
38.     Feng, L., Xie, X., Joshi, P., Yang, Z., Shibasaki, K., Chow, R., and Gan, L. (2006). Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development, 4815-4825. doi:10.1242/dev.02664 (杂志封面).
39.     Shibasaki, K., Takebayashi, H., Ikenaka, K., Feng, L., and Gan, L. (2007). Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells. Gene Expr Patterns 7, 57-65.
40.     Elshatory, Y., Deng, M., Xie, X., and Gan, L. (2007). Expression of the LIM-homeodomain protein Isl1 in developing mouse retina: evidence for a role in the neuronal differentiation of retinal bipolar, amacrine and ganglion cells. J. Comp. Neurol. 503, 182–197. DOI 10.1002/cne.21390.
41.     Elshatory, Y., Deng, M., Xie, X., Barlow, R.B., and Gan, L. (2007). Islet-1 Controls the Differentiation of Retinal Bipolar and Cholinergic Amacrine Cells. J. Neurosci. 27:12707-12720; doi:10.1523/JNEUROSCI.3951-07.2007.
42.     Pan, L., Deng, D., Xie, X., and Gan, L. (2008). Isl1 and Brn3b co-regulate the differentiation of murine retinal ganglion cells. Development 135, 1981-1990. doi: 10.1242/dev.010751. (杂志封面).
43.     Elshatory, Y. and Gan, L. (2008). The LIM-Homeobox Gene Islet-1 Is Required for the Development of Restricted Forebrain Cholinergic Neurons. J. Neurosci. 28:3291–3297. DOI:10.1523/JNEUROSCI.5730-07.2008.
44.     Joshi, P.S., Molyneaux, B.J., Feng, L., Xie, X., Macklis, J., and Gan, L. (2008). Bhlhb5 Regulates the Post-Mitotic Acquisition of Area Identities in Layers II-V of the Developing Neocortex. Neuron 60, 258–272. doi:10.1016/j.neuron.2008.08.006.
45.     Ding, Q., Chen, H., Xie, X., Libby, R., Tian, N., and Gan, L. (2009). BARHL2 differentially regulates the development of retinal amacrince and ganglion neurons. J. Neurosci. 29, 3992– 4003. (杂志封面). doi:10.1523/JNEUROSCI.5237-08.2009.
46.     Sakagami, K., Gan, L., and Yang, X-J. (2009). Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J. Neurosci. 29(21):6932-6944; doi:10.1523/JNEUROSCI.0289-09.2009.
47.     Xu, H., Chen, H., Ding, Q., Xie, Z-H, Chen, L., Diao, L., Wang, P., Gan, L., Crair, M.C., and Tian, N. (2010). Is Required forzThe Immune Protein CD3 Normal Development of Neural Circuits in the Retina. Neuron65, 503-515.
48.     Deng, M., Pan, L., Xie, X., and Gan, L. (2010). Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev. Biol. 338, 38–49(published online on Nov. 10, 2009). (杂志封面)
49.     Hwang, C.H., Guo, D., Harris, M.A., Mishina, Y., Gan, L., Harris, S.E., and Wu, D.K. (2010). The role of BMPs on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice. Dev. Dyn. 239, 505-13.
50.     Yang, H., Xie, X., Deng, M., Chen, X., and Gan, L. (2010). Generation and characterization of Atoh1-Cre knock-in mouse line. Genesis 48, 407–413. (杂志封面).
51.     Yang, H., Gan, J., Xie, X., Deng, M., Chen, X., Gao, Z., and Gan, L. (2010). Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion. Genesis 48, 400–406.
52.     Feng, L., Xie, Z., Ding, Q., Xie, X., Libby, R., and Gan, L. (2010). Math5 Controls the Acquisition of Multiple Retinal Cell Fates. Molecular Brain 3(1):36. Epub 2010 Nov 18.
53.     Berahovich, R.D., Zabel, B.A., Penfold, M.E., Lewen, S., Wang, Y., Miao, Z., Gan, L., Pereda, J., Dias, J., Slukvin, I.I., McGrath, K.E., Jaen, J.C., and Schall, T.J. (2010). CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 185, 5130-9.
54.     Whitney, I.E., Raven, M.A., Ciobanu, D.C., Poch, R.A., Ding, Q., Elshatory, Y., Gan, L., Williams, R.W., and Reese, B.E. (2011). Genetic Modulation of Horizontal Cell Number in the Mouse Retina. Proc. Natl. Sci. Acad., USA. 108, 9697-702.

 

  

 

 

 

 

 

 

 

 

 

 

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